Chemistry for chemical genomics.
نویسنده
چکیده
New methods and strategies have been developed to design and use small molecules that allow the functional dissection of molecular pathways, cells, and organisms by selective small-molecule ligands or modulators. In this overview, we are focusing on diversity aspects, design methods, and chemical synthesis strategies for the application of small molecules as tools for chemical genomics. Examples for different successful chemical-genomics strategies include the selection of diverse drug-like molecules, target family-focused compound libraries, natural-product chemistry, and diversity-oriented synthesis.
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Molecular Science and Biomedicine L Chemo/Bio-Sensing and Chemometrics, Chemistry and Chemical Engineering, A Province, Hunan University, Changsha, Hun ac.cn. Center for Research at Bio/Nano Interface, Physiology and Functional Genomics, Heal McKnight Brain Institute, University of Fl USA. E-mail: [email protected].edu George & Josephine Butler Polymer Researc Science & Engineering, Department of Che...
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عنوان ژورنال:
- Methods in molecular biology
دوره 310 شماره
صفحات -
تاریخ انتشار 2005